Mantle Cell Lymphoma (MCL)

WHAT IS MANTLE CELL LYMPHOMA (MCML)?

Mantle Cell Lymphoma is a type of cancer in the lymphatic system caused by uncontrolled growth of B lymphocytes found in the follicular mantle area of the lymph nodes. MCL accounts for 6% of non-Hodgkin’s lymphomas.

The increase of malignant or abnormal B lymphocytes in the bone marrow leaves little space for red blood cells or platelets, therefore, their quantity decreases. This leads to the appearance of symptoms such as fatigue or an increased susceptibility to infections.
B cells can accumulate in lymph nodes or organs such as the spleen, liver, intestines, among others; this is perceived as inflammation of the nodes or the organ where they are located.

Signs and symptoms of mantle cell lymphoma

Heavy night sweats
Heavy night sweats
Severe fatigue
Severe fatigue
Fever without proof of infection
Fever without proof of infection
Unplanned weight loss (loss of more than 10% of initial weight in less than 6 months)
Unplanned weight loss (loss of more than 10% of initial weight in less than 6 months)
Swollen lymph nodes
Swollen lymph nodes
Enlargement of the liver
Enlargement of the liver
Enlargement of the spleen
Enlargement of the spleen

CC-10181 / JUNE 2025

National Comprehensive Cancer Network Guidelines for Patients: Mantle Cell Lymphoma, NCCC Non Hodgkin Lymphoma Series, 2017.

Janssen-Cilag. Linfoma de Células del Manto, 2018. Disponible en: https://www.cancerdelasangre.com/soy-paciente/linfoma-de-celulas-del-manto/

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